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THERAPEUTIC DOOR OPENS FOR AGGRESIVE BRAIN CANCER

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The clinical trial that Andrea entered represents the first step of a novel anti-cancer strategy intended to treat both the tumor and swelling. The approach arises from decades of basic research on the biology and physiology of solid tumors. But it took a three-part collaboration of Massachusetts General Hospital specialists in cancer biology, brain imaging and medicine to translate the approach from the laboratory to patient care.
Rakesh K. Jain, PhD

Opening a Window of Opportunity

Cediranib belongs to a class of drugs called antiangiogenics. Rather than killing the cancer cells, the approach of traditional chemotherapy drugs, antiangiogenics target the abnormal blood vessels that “feed” the cancer. Shutting down the blood supply “starves” the tumor, and it begins to wither. Eventually, though, tumors recruit new blood vessels and the cancer rebounds.

Many other biological processes also go awry, discovered Rakesh K. Jain, PhD, the A. W. Cook Professor of Tumor Biology at Harvard University and Director of the E. L. Steele Laboratory of Tumor Biology in the Department of Radiation Oncology at Massachusetts General Hospital. His studies in model systems showed that a tumor’s blood vessels become increasingly leaky. Fluids ooze out of the vessels, creating high pressure inside the tumor. The pressure pushes fluids out of the tumor, causing brain swelling. The internal pressure also pushes away chemotherapy drugs that need to enter the tumor to work. The vessels become twisted and kinked, causing blood to slow or even flow backward. The malfunctioning vessels also produce low oxygen and high acidity in the tumor, which renders it resistant to chemotherapy and radiation. If these problems could be fixed, a window of opportunity would open during which traditional anti-cancer treatments could be more effective. An engineer turned biologist, Jain wanted to find this window. Using a model system, he discovered that anti angiogenics did more than temporarily shrink tumors: They also straightened the blood vessels and restored blood flow, giving chemotherapy drugs easier access to the cancer cells. They rebalanced oxygen and acidity levels, helping the anti-cancer medications work more effectively. And they closed the leaks, reduced the pressure, and shrank the swelling.

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Advancing the Specialized Care of Individuals with Brain Tumors
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MGH Brain Tumor Center
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Boston, Massachusetts,  02114
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Patients & Families with questions about referrals, consultations or appointments may contact:
Telephone: 617.724.8770
Fax: 617.724.8769

PHYSICIANS' INFO SERVICE

Physicians with
questions may contact:
Tracy Batchelor, M.D.
Executive Director,
MGH Brain Tumor Center
 
Harvard Medical School
Mass General Hospital
MassGeneral.org
MGH Cancer Center
NS @ MGHNS Diagnosis @ MGH
Disclaimer About Medical Information: The information and reference materials contained herein is intended solely for the information of the reader. It should not be used for treatment purposes, but rather for discussion with the patient's own physician. All visitors to this and associated sites from the Neurosurgical Service at MGH agree to read and abide by the the complete terms of legal agreement found at the Neurosurgery "disclaimer & legal agreement." See also: the MGH Disclaimer, the MGH Privacy Policy, and the MGH Interactive Program Disclaimer - Copyright 2008 MGH Neurosurgical Service - All Rights Reserved. System Info Contact: C.Owen
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