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Complex Systems



Brain Tumor Center @ MGH 

Neurosurgery @ MGH

Research @ MGH Neurosurgery

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  • Kansal A.R., Torquato S., Harsh IV G.R., Chiocca E.A., and Deisboeck T.S.: Cellular automaton of idealized brain tumor growth dynamics. Biosystems 55: 119-127, 2000.
  • Kansal A.R., Torquato S., Harsh IV G.R., Chiocca E.A., and Deisboeck T.S.: Simulated brain tumor growth dynamics using a three-dimensional cellular automaton. J. theor. Biol. 203: 367-382, 2000.
  • Kansal A.R., Torquato S., Chiocca E.A., and Deisboeck T.S.: Emergence of a subpopulation in a computational model of tumor growth. J. theor. Biol. 207: 431-441, 2000.
  • Deisboeck T.S., Berens M.E., Kansal A.R., Torquato S., Stemmer-Rachamimov A.O., and Chiocca E.A.: Pattern of self-organization in tumor systems: complex growth dynamics in a novel brain tumor spheroid model. Cell Prolif. 34: 115-134, 2001.
  • Zhang S., Demiralp C., DaSilva M., Keefe D., Laidlaw D., Greenberg B.D., Basser P.J., Pierpaoli C., Chiocca E.A., and Deisboeck T.S.: Toward applications of virtual reality to visualization of DT-MRI volumes. Lecture Notes in Comp. Science 2008: 1406-1408, 2001.
  • Mojsilovic A., Rogowitz B., Gomez J., and Deisboeck T.S.: Analysis, reconstruction and visualization of malignant brain tumors: a case study in data synthesis. Analyt. Quant. Cytol. Histol. 24: 125-133, 2002.
  • Mansury Y., M. Kimura, Lobo J., and Deisboeck T.S.: Emerging pattern in tumor systems: simulating the complex dynamics of multicellular cluster structures by using a novel agent-based spatio-temporal agglomeration model. J. theor. Biol. 219: 343-370, 2002.
  • Sander L.M. and Deisboeck T.S.: Growth patterns of microscopic brain tumors. Phys. Rev. E 66: 051901, 2002 (Also selected for Publication in Virtual Journal of Biol. Physics Research 4 (10), 2002).
  • Mansury Y. and Deisboeck T.S.: The impact of ‘search precision’ in an agent-based tumor model. J. theor. Biol. 224: 325-337, 2003.
  • Habib S., Molina-Paris C., and Deisboeck T.S.: Complex dynamics of tumors: modeling an emerging brain tumor system using a set of coupled reaction-diffusion equations. Physica A. 327: 501-524, 2003.
  • Gordon V.D., Valentine M.T., Gardel M.L., Andor D., Dennison S., Bogdanov A.A., Weitz D.A., and Deisboeck T.S.: Measuring the mechanical stress induced by an expanding multicellular tumor system: a case study. Exp. Cell Res. 289 (1): 58-66, 2003.
  • Guiot C., DeGiorgis P.G., Delsanto P.P., Gabriele P., and Deisboeck T.S.: Does tumor growth follow a universal’ law? J. theor. Biol. 225: 147-283, 2003.
  • Mansury Y. and Deisboeck T.S.: Simulating 'structure-function' patterns of malignant brain tumors. Physica A. 331: 219-232, 2004.
  • Zhang S., Bastin M.E., Laidlaw D.H., Sinha S., Armitage P.A., and Deisboeck T.S.: Visualization and analysis of white matter structural asymmetry in diffusion-tensor MR imaging data. Magn. Reson. Med. 51(1): 140-147, 2004.
  • Sole R.V. and Deisboeck T.S.: An error catastrophe in cancer? J. theor. Biol. 228: 47-54, 2004.
  • Delsanto P.P., Guiot C., Degiorgis P.G., Condat C.A., Mansury Y., and Deisboeck T.S.: A growth model for multicellular tumor spheroids.Submitted.
  • Mansury Y. and Deisboeck T.S.: Simulating the time series of a selected gene expression profile in an agent-based tumor model.Submitted.
  • Deisboeck T.S., Mansury Y., Guiot C., Degiorgis P.G., and Delsanto P.P.: Insights from a novel tumor model: Indications for a quantitative link between tumor growth and invasion.Submitted.
Disclaimer: The information and reference materials contained herein is intended solely for  the information of the reader. It should not be used for treatment purposes, but rather for  discussion  with the patient's own physician. Information on this site. Copyright99.
CONTACT INFORMATION: All general inquiries about the project as well as all questions regarding assay engineering, underlying tumor modeling concepts and complex biosystems modeling should be sent to Thomas S. Deisboeck, M.D  
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